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Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)
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Service Source Final Application Due Date Funding Available Match Required
Health Care Federal
HHS
02-17-2026 N/A No Match
Required
  • Service
  • Source
  • Final Application Due Date
  • Funding Available
  • Match Required
Status
  • Past
  • Current
  • Forecasted
    • Opportunity Type Discretionary
    • CFDA

      93.350 -- National Center for Advancing Translational Sciences

    Description

    TheNational Center for Advancing Translational Science (NCATS) seeks to advance its mission byadvancing research on extracellular vesicles (EVs) and their use as therapeutics in the field of regenerative medicine.

    The main objective of this program,Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe), is to supportthe translation of EV-based therapeutics in regenerative medicine. EVs, like exosomes and microvesicles, are crucial mediators of intercellular communication, carrying diverse cargo like proteins, nucleic acids, and lipids. In regenerative medicine, EVs play a significant role by influencing cellular behaviors during tissue repair and regeneration. Due to their natural function in intercellular communication, EVs represent a novel, cell-free, therapeutic tool. EVs can be further engineered to deliver therapeutic agents or modulate signaling pathways involved in repair/regeneration.

    Areas of interest for ExTReMe could include, but are not limited to:

    1. direct EV therapy (stem cell-isolated EVs produced under GLP conditions, and stored as off-the-shelf therapies);
    2. designer EVs (personalized to the individual patient’s needs).

    Grant authorities that allow theNational Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network

    Eligibility
    • IHE
    • Local Government
    • Non-Profit
    • Other
    • State Government
    • Tribal Government
    Key Date(s)
    • June 27, 2025: Last Updated Date
    • June 27, 2025: Forecasted Date
    • October 15, 2025: Estimated Post Date
    • February 17, 2026: Estimated Application Due Date
    • December 17, 2026: Estimated Award Date
    • January 18, 2027: Estimated Project Start Date
    Contact Information
    Christine Happel, Ph.D. National Center for Advancing Translational Sciences (NCATS) 240-472-7550 christine.happel@nih.gov

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