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Biomedical Research Initiative for Next-Gen BioTechnologies - SynBio Control
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Service Source Final Application Due Date Funding Available Match Required
Science & Technology Federal
NSF
12-04-2024 $2.4 M No Match
Required
  • Service
  • Source
  • Final Application Due Date
  • Funding Available
  • Match Required
Status
  • Past
  • Current
  • Forecasted
  • $300,000
  • N/A
  • Award Floor
  • Award Ceiling
    • Expected Number of Awards 8
    • Opportunity Type Discretionary
    • CFDA

      47.041 -- Engineering

      93.286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health

    Description

    The National Science Foundation Directorate for Engineering (NSF/ENG) and the National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) announce the Biomedical Research Initiative for Next-Gen BioTechnologies – SynBio Control (BRING-SynBio) Solicitation. The BRING – SynBio Control solicitation aims to accelerate the translation of novel fundamental synthetic and engineering biology advances to early-stage biomedical technologies through interagency collaboration. Projects responsive to the BRING–SynBio solicitation will include a two-phased plan to pursue proof of principle synthetic and engineering biology research (Phase I) and exploratory research to translate findings toward biomedical technologies (Phase II). Phase II research should build on the projected outcomes of Phase I. NSF will provide support for fundamental research activity in Phase I. NIH will provide support for exploratory biomedical engineering technology development in Phase II. Successful completion of Phase I milestones will be administratively evaluated by NIH/NIBIB to determine eligibility to transition to Phase II. This transition is neither automatic nor guaranteed. Potential areas of interest for BRING–SynBio include but are not limited to: Novel design principles for the characterization and design of new synthetic biology tools and parts:

    • Gene circuit designs that enhance robustness, reliability, predictability, and tuneability of current designs.
    • Modular designs for tools and parts that, when combined, result in predictable network outcomes.
    • New strategies to improve upon size limitations of gene circuit designs.
    Regulation and control of biological processes in cells/tissues:
    • Synthetic gene regulatory networks for controlled modulation of gene expression and dynamic noise filtering.
    • Design of synthetic circuits that incorporate novel feedback control strategies.
    Projects that address only one of the phases, do not pursue advances in synthetic biology that incorporate biological control theory, or do not address a challenge with clear relevance to the mission of NIBIB are non-responsive. Non-responsive projects will be returned without review.

    Eligibility
    • IHE
    • Local Government
    • Non-Profit
    • Other
    • State Government
    • Tribal Government
    Additional Eligibility Information

    *Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members.Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.

    Key Date(s)
    • September 06, 2024: Last Updated Date
    • September 06, 2024: Posted Date
    • December 04, 2024: Current Closing Date for Applications
    • December 04, 2024: Application Due Date
    • January 03, 2025: Application Archive Date
    Contact Information

    NSF grants.gov support

    grantsgovsupport@nsf.gov

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